Journal article
Stereodivergent total synthesis of Δ9-tetrahydrocannabinols.
- Schafroth MA Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, HCI H335, Vladimir-Prelog-Weg 3, Zürich (Switzerland) http://www.carreira.ethz.ch.
- Zuccarello G
- Krautwald S
- Sarlah D
- Carreira EM
- 2014-10-11
Published in:
- Angewandte Chemie (International ed. in English). - 2014
dual catalysis
stereodivergent synthesis
tetrahydrocannabinol
total synthesis
Dronabinol
Stereoisomerism
English
All four stereoisomers of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1002/anie.201408380
- PMID 25303495
- Persistent URL
- https://sonar.ch/global/documents/199446
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