Journal article
Guiding ligands to nuclear receptors.
- Michalik L Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Switzerland.
- Wahli W
- 2007-05-22
Published in:
- Cell. - 2007
Active Transport, Cell Nucleus
Animals
Apoptosis
Cell Nucleus
Cell Survival
Humans
Ligands
PPAR-beta
Receptors, Retinoic Acid
Signal Transduction
Tretinoin
English
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.cell.2007.05.001
- PMID 17512397
- Persistent URL
- https://sonar.ch/global/documents/19948
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