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GABA and glutamate neurons in the VTA regulate sleep and wakefulness.

  • Yu X Department of Life Sciences, Imperial College London, London, UK.
  • Li W Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
  • Ma Y Department of Life Sciences, Imperial College London, London, UK.
  • Tossell K Department of Life Sciences, Imperial College London, London, UK.
  • Harris JJ Department of Life Sciences, Imperial College London, London, UK.
  • Harding EC Department of Life Sciences, Imperial College London, London, UK.
  • Ba W Department of Life Sciences, Imperial College London, London, UK.
  • Miracca G Department of Life Sciences, Imperial College London, London, UK.
  • Wang D Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
  • Li L Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
  • Guo J Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
  • Chen M iHuman Institute, ShanghaiTech University, Shanghai, China.
  • Li Y Department of Life Sciences, Imperial College London, London, UK.
  • Yustos R Department of Life Sciences, Imperial College London, London, UK.
  • Vyssotski AL Institute of Neuroinformatics, University of Zürich/ETH Zürich, Zürich, Switzerland.
  • Burdakov D The Francis Crick Institute, London, UK.
  • Yang Q Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
  • Dong H Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China. hldong6@hotmail.com.
  • Franks NP Department of Life Sciences, Imperial College London, London, UK. n.franks@imperial.ac.uk.
  • Wisden W Department of Life Sciences, Imperial College London, London, UK. w.wisden@imperial.ac.uk.
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  • 2018-12-19
Published in:
  • Nature neuroscience. - 2019
Animals
Dopaminergic Neurons
GABAergic Neurons
Glutamic Acid
Mice
Neurons
Nitric Oxide Synthase Type I
Sleep
Sleep, REM
Ventral Tegmental Area
Wakefulness
English We screened for novel circuits in the mouse brain that promote wakefulness. Chemogenetic activation experiments and electroencephalogram recordings pointed to glutamatergic/nitrergic (NOS1) and GABAergic neurons in the ventral tegmental area (VTA). Activating glutamatergic/NOS1 neurons, which were wake- and rapid eye movement (REM) sleep-active, produced wakefulness through projections to the nucleus accumbens and the lateral hypothalamus. Lesioning the glutamate cells impaired the consolidation of wakefulness. By contrast, activation of GABAergic VTA neurons elicited long-lasting non-rapid-eye-movement-like sleep resembling sedation. Lesioning these neurons produced an increase in wakefulness that persisted for at least 4 months. Surprisingly, these VTA GABAergic neurons were wake- and REM sleep-active. We suggest that GABAergic VTA neurons may limit wakefulness by inhibiting the arousal-promoting VTA glutamatergic and/or dopaminergic neurons and through projections to the lateral hypothalamus. Thus, in addition to its contribution to goal- and reward-directed behaviors, the VTA has a role in regulating sleep and wakefulness.
Language
  • English
Open access status
green
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https://sonar.ch/global/documents/199672
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