Back
Magnetically actuated microrobots as a platform for stem cell transplantation.
Journal article

Magnetically actuated microrobots as a platform for stem cell transplantation.

  • Jeon S Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, South Korea.
  • Kim S Institute of Robotic and Intelligent System (IRIS), ETH, Zurich 8092, Switzerland.
  • Ha S Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Lee S Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, South Korea.
  • Kim E Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, South Korea.
  • Kim SY Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Park SH Postech-Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Jeon JH Postech-Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Kim SW Postech-Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Moon C Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
  • Nelson BJ Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, South Korea.
  • Kim JY Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, South Korea. mems@dgist.ac.kr yusw@dgist.ac.kr jy.kim@dgist.ac.kr.
  • Yu SW Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea. mems@dgist.ac.kr yusw@dgist.ac.kr jy.kim@dgist.ac.kr.
  • Choi H Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, South Korea. mems@dgist.ac.kr yusw@dgist.ac.kr jy.kim@dgist.ac.kr.
Show more…
  • 2020-11-02
Published in:
  • Science robotics. - 2019
English Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/199780
Statistics
Document views: 6 File downloads: