Journal article
Distribution of the 4-aminopyridine derivative 3-methoxy-4-aminopyridine in mice.
- Berger SG Institute of Pharmacology University of Zurich, Switzerland.
- Waser PG
- Chang Sin-Ren A
- 1989-02-01
Published in:
- Neuropharmacology. - 1989
4-Aminopyridine
Aminopyridines
Animals
Autoradiography
Carbon Radioisotopes
Injections, Intravenous
Male
Mice
Tissue Distribution
English
The tissue distribution of [14C]3-Methoxy-4-aminopyridine was studied after intravenous administration in mice using whole body and microautoradiography. Dense accumulation was found in cholinergically innervated, secretory organs. High radioactivity was detected in the adrenal medulla suggesting that the observed excitement and hyperglycemia are due to the stimulation of catecholamine secretion. [14C]3-Methoxy-4-aminopyridine quickly passes the blood brain barrier and predominantly accumulates in the hippocampus, the thalamic nuclei and the cortex.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/0028-3908(89)90056-7
- PMID 2716971
- Persistent URL
- https://sonar.ch/global/documents/200002
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