Journal article
The phylogeny of the insulin-like growth factors.
- Reinecke M Division of Neuroendocrinology, University of Zürich, Switzerland.
- Collet C
- 1998-07-17
Published in:
- International review of cytology. - 1998
Amino Acid Sequence
Animals
Evolution, Molecular
Humans
Molecular Sequence Data
Phylogeny
Somatomedins
English
The insulin-like growth factors are major regulators of growth and development in mammals and their presence in lower vertebrates suggests that they played a similarly fundamental role throughout vertebrate evolution. While originally perceived simply as mediators of growth hormone, on-going research in mammals has revealed several hierarchical layers of complexity in the regulation of ligand bioavailability and signal transduction. Our understanding of the biological role and mechanisms of action of these important growth factors in mammals patently requires further elucidation of the IGF hormone system in the simple model systems that can be found in lower vertebrates and protochordates. This review contrasts our knowledge of the IGF hormone system in mammalian and nonmammalian models through comparison of tissue and developmental distributions and gene structures of IGF system components in different taxa. We also discuss the evolutionary origins of the system components and their possible evolutionary pathways.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0074-7696(08)60142-4
- PMID 9666565
- Persistent URL
- https://sonar.ch/global/documents/200110
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