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Direct Mechanical Intervention Versus Bridging Therapy in Stroke Patients Eligible for Intravenous Thrombolysis: A Pooled Analysis of 2 Registries.
Journal article

Direct Mechanical Intervention Versus Bridging Therapy in Stroke Patients Eligible for Intravenous Thrombolysis: A Pooled Analysis of 2 Registries.

  • Bellwald S From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Weber R From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Dobrocky T From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Nordmeyer H From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Jung S From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Hadisurya J From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Mordasini P From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Mono ML From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Stracke CP From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Sarikaya H From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Bernasconi C From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Berger K From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Arnold M From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Chapot R From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Gralla J From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.).
  • Fischer U From the Department of Neurology (S.B., S.J., M.-L.M., H.S., C.B., M.A., U.F.) and Department of Diagnostic and Interventional Neuroradiology (S.B., T.D., P.M., J.G.), Inselspital, University Hospital Bern and University of Bern, Switzerland; Department of Neurology (R.W., J.H.) and Department of Radiology and Neuroradiology (H.N., C.P.S., R.C.), Alfried Krupp Krankenhaus Essen, Germany; and Institute of Epidemiology and Social Medicine, University of Münster, Germany (K.B.). urs.fischer@insel.ch.
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  • 2017-11-09
Published in:
  • Stroke. - 2017
bridging thrombolysis
mechanical thrombectomy
propensity score
registries
thrombectomy
Administration, Intravenous
Aged
Aged, 80 and over
Carotid Stenosis
Coronary Disease
Female
Fibrinolytic Agents
Humans
Intracranial Hemorrhages
Male
Middle Aged
Propensity Score
Registries
Stroke
Thrombectomy
Thrombolytic Therapy
Treatment Outcome
English BACKGROUND AND PURPOSE
Randomized controlled trials have shown that mechanical thrombectomy (MT) plus best medical treatment improves outcome in stroke patients with large-vessel occlusion in the anterior circulation. Whether direct MT is equally effective as bridging thrombolysis (intravenous thrombolysis plus MT) in intravenous thrombolysis eligible patients remains unclear.


METHODS
We compared clinical and radiological outcomes at 3 months in 249 bridging patients with 111 patients receiving direct MT for large-vessel occlusion anterior circulation stroke from 2 prospective registries (study period Essen: June 2012 to August 2013, Bern February 2009 to August 2014). We matched all patients from the direct MT group who would have qualified for intravenous thrombolysis with controls from the bridging group, using multivariate and propensity score methods. Subgroup analyses for internal carotid artery occlusions were performed.


RESULTS
Baseline characteristics did not differ between the direct MT group and bridging cohort, except for higher rates of coronary heart disease (P=0.029) and shorter intervals from onset to endovascular therapy (P<0.001) in the MT group. Functional outcome, mortality, and intracerebral hemorrhage did not differ, neither in univariate nor after multivariate and propensity score matching. However, in patients with internal carotid artery occlusion, mortality in the direct cohort was significantly lower.


CONCLUSIONS
In this matched-pair analysis, there was no difference in outcome in patients with large-vessel occlusion anterior circulation stroke treated with direct MT compared with those treated with bridging thrombolysis; however, mortality in patients with internal carotid artery occlusion treated with direct MT was significantly lower than after bridging thrombolysis. Randomized trials comparing direct MT with bridging therapy are needed.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/201364
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