Journal article
Patent Foramen Ovale and Hypoxemia.
- Mojadidi MK From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL.
- Ruiz JC Department of Medicine, Albert Einstein College of Medicine (Jacobi Program), New York, NY.
- Chertoff J Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida College of Medicine, Gainesville, FL.
- Zaman MO From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL.
- Elgendy IY From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL.
- Mahmoud AN From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL.
- Al-Ani M From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL.
- Elgendy AY From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL.
- Patel NK Division of Cardiovascular Medicine, Virginia Commonwealth University, Richmond, VA.
- Shantha G Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA.
- Tobis JM Program in Interventional Cardiology, Division of Cardiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.
- Meier B Department of Cardiology, University Hospital of Bern, Bern, Switzerland.
- 2018-03-24
Published in:
- Cardiology in review. - 2019
English
Patent foramen ovale (PFO), an embryonic remnant of the fetal circulation, is present in 20-25% of adults. Although recent observational studies and clinical trials have established the link between PFO-mediated right-to-left shunting with cryptogenic stroke and migraine with aura, the role of a PFO in exacerbating hypoxemic medical conditions (ie, sleep apnea, chronic obstructive pulmonary disease, pulmonary hypertension, platypnea-orthodeoxia, pulmonary arteriovenous malformation, high-altitude pulmonary edema, and exercise desaturation) remains less understood. PFO-mediated hypoxemia occurs when deoxygenated venous blood from the right atrium enters and mixes with oxygenated arterial blood in the left atrium. Patients with an intracardiac right-to-left shunt may have profound hypoxemia out of proportion to underlying primary lung disease, even in the presence of normal right-sided pressures. The presence of right-to-left cardiac shunting can exacerbate the degree of hypoxemia in patients with underlying pulmonary disorders. In a subset of these patients, percutaneous PFO closure may result in marked improvement in dyspnea and hypoxemia. This review discusses the association between PFO-mediated right-to-left shunting with medical conditions associated with hypoxemia and explores the role of percutaneous PFO closure in alleviating the hypoxemia.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1097/CRD.0000000000000205
- PMID 29570476
- Persistent URL
- https://sonar.ch/global/documents/201501
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