Targeting inflammation in the treatment of type 2 diabetes.
- Donath MY Department of Endocrinology, Diabetes & Metabolism, University Hospital Basel, Basel, Switzerland. marc.Donath@usb.ch
- 2013-09-06
Published in:
- Diabetes, obesity & metabolism. - 2013
cytokines
immunometabolism
insulin
Animals
Diabetes Mellitus, Type 2
Humans
Hypoglycemic Agents
Inflammation
Islets of Langerhans
Molecular Targeted Therapy
English
Islets of patients with type 2 diabetes display the typical features of an inflammatory process characterized by the presence of cytokines, chemokines, immune cell infiltration, impaired function and tissue destruction with fibrotic areas. Functional studies have shown that targeting inflammation may improve insulin secretion and sensitivity. In particular clinical proof of concept studies using modulators of the interleukin-1β (IL-1β)-nuclear factor--κB (NF-κB) pathway demonstrated the role of the innate immune system in type 2 diabetes. This programme has now entered the phase 3 of clinical development. Other targets such as tumour necrosis factor α (TNFα) may be equally important but have been neglected based on poorly designed studies. In this article we discuss the mechanisms of islet inflammation in type 2 diabetes and review the opportunity of clinical translation.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1111/dom.12172
- PMID 24003937
- Persistent URL
- https://sonar.ch/global/documents/201934
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