Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".
- Vassalli A Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland. mehdi.tafti@unil.ch anne.vassalli@unil.ch.
- Li S Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland.
- Tafti M Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland. mehdi.tafti@unil.ch anne.vassalli@unil.ch.
- 2015-11-20
Published in:
- Science translational medicine. - 2015
English
Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et al. now show that hypocretin neurons (whose loss causes narcolepsy) do not express hypocretin autoreceptors, raising questions to the interpretation of Ahmed et al.'s findings.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1126/scitranslmed.aad2353
- PMID 26582896
- Persistent URL
- https://sonar.ch/global/documents/20222
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