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European Group for Blood and Marrow Transplantation Centers with FACT-JACIE Accreditation Have Significantly Better Compliance with Related Donor Care Standards.

  • Anthias C Anthony Nolan Research Institute, London, United Kingdom. Electronic address: chloeanthias@anthonynolan.org.
  • O'Donnell PV Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Kiefer DM Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN, USA.
  • Yared J Department of Medicine, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Norkin M Division of Hematology/Oncology, University of Florida, Florida College of Medicine, Gainesville, FL, USA.
  • Anderlini P The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Savani BN Division of Hematology/Oncology, Vanderbilt Medical Center, Nashville, TN, USA.
  • Diaz MA Department of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.
  • Bitan M Tel-Aviv Sourasky Medical Center, Israel.
  • Halter JP Department of Haematology, University Hospital Basel, Switzerland.
  • Logan BR Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Switzer GE University of Pittsburgh, VA Medical Healthcare System, Pittsburgh, PA, USA.
  • Pulsipher MA Children's Hospital of Los Angeles, USC Keck School of Medicine, Los Angeles, CA, USA.
  • Confer DL National Marrow Donor Program/Be The Match, Minneapolis, MN, USA.
  • Shaw BE Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
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  • 2015-11-25
Published in:
  • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. - 2016
Accreditation
Hematopoietic cell donation
JACIE
Related donor
Accreditation
Donor Selection
Europe
Female
Guideline Adherence
Hematopoietic Stem Cell Transplantation
Humans
Male
Retrospective Studies
Unrelated Donors
English Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to Foundation for the Accreditation of Cellular Therapy/The Joint Accreditation Committee ISCT and EBMT (FACT-JACIE) Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of European Group for Blood and Marrow Transplantation member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared with nonaccredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P = .02), and a lower percentage have a single physician simultaneously responsible for an RD and their recipient (14% versus 35%; P = .008). In contrast, where regulatory standards do not exist, both accredited and nonaccredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care.
Language
  • English
Open access status
hybrid
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Persistent URL
https://sonar.ch/global/documents/202458
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