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Pitfalls in FMRI.
Journal article

Pitfalls in FMRI.

  • Haller S Institute of Radiology, Department of Neuroradiology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland. shaller@uhbs.ch
  • Bartsch AJ
  • 2009-06-09
Published in:
  • European radiology. - 2009
Artifacts
Brain
Brain Mapping
Echo-Planar Imaging
Electroencephalography
False Positive Reactions
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Movement
Neurons
Oxygen
Principal Component Analysis
Reproducibility of Results
Time Factors
English Several different techniques allow a functional assessment of neuronal activations by magnetic resonance imaging (fMRI). The by far most influential fMRI technique is based on a local T2*-sensitive hemodynamic response to neuronal activation, also known as the blood oxygenation level dependent or BOLD effect. Consequently, the term 'fMRI' is often used synonymously with BOLD imaging. Because interpretations of fMRI brain activation maps often appear intuitive and compelling, the reader might be tempted not to critically question the fundamental processes and assumptions. We review some essential processes and assumptions of BOLD fMRI and discuss related confounds and pitfalls in fMRI - from the underlying physiological effect, to data acquisition, data analysis and the interpretation of the results including clinical fMRI. A background framework is provided for the systematic and critical interpretation of fMRI results.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/202534
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