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The role of nucleocytoplasmic transport in mechanotransduction.
Journal article

The role of nucleocytoplasmic transport in mechanotransduction.

  • Kassianidou E Biozentrum and the Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
  • Kalita J Biozentrum and the Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
  • Lim RYH Biozentrum and the Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. Electronic address: roderick.lim@unibas.ch.
  • 2019-02-16
Published in:
  • Experimental cell research. - 2019
Active Transport, Cell Nucleus
Animals
Cell Nucleus
Cytoplasm
Humans
Mechanotransduction, Cellular
Phosphoproteins
Transcription Factors
English Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling. While the force-sensing and force-transducing mechanisms are generally known, it remains unclear how mechanoresponsive transcription factors (TFs) are selectively translocated into the nucleus upon force activation. Such TFs include Yes-Associated Protein (YAP), Myocardin Related Transcription Factors (MRTFs), Hypoxia Induced Factors (HIFs) and others. Here, we discuss how the nucleocytoplasmic transport machinery intersects with mechanoresponsive TFs to facilitate their selective transport through nuclear pore complexes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/202676
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