Journal article
Down's syndrome screening at 11-14 weeks' gestation using prenasal thickness and nasal bone length.
- Manegold-Brauer G Department of Prenatal Medicine and Gynecologic Ultrasound, University of Basel, Women's Hospital, Spitalstrasse 21, 4031, Basel, Switzerland. gwendolin.manegold-brauer@usb.ch.
- Maymon R Department of Obstetrics and Gynecology, Institute of Ultrasound, Sackler School of Medicine, Assaf Harofeh Medical Centre, Beer Yakov 70300, Tzrifin, Israel.
- Shor S Department of Obstetrics and Gynecology, Institute of Ultrasound, Sackler School of Medicine, Assaf Harofeh Medical Centre, Beer Yakov 70300, Tzrifin, Israel.
- Cuckle H Department of Obstetrics and Gynecology, Columbia University Medical Center, Columbia University, 622 West 168th Street, New York, NY, 10032, USA.
- Gembruch U Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.
- Geipel A Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.
- 2019-02-11
Published in:
- Archives of gynecology and obstetrics. - 2019
Down's syndrome
First trimester
Nasal bone length
Prenasal thickness
Screening
Adolescent
Adult
Down Syndrome
Female
Fetus
Gestational Age
Humans
Mass Screening
Middle Aged
Nasal Bone
Nuchal Translucency Measurement
Pregnancy
Pregnancy Trimester, First
Prospective Studies
Ultrasonography, Prenatal
Young Adult
English
PURPOSE
To perform a multicenter prospective study of ultrasound prenasal thickness (PT), and nasal bone length (NBL) measurement at 11-14 weeks' gestation.
METHODS
Ultrasound PT and NBL determination was performed in 504 normal fetuses and 17 fetuses with Down's syndrome (DS). Measurements were made from mid-sagittal 2D images acquired using a standardized technique during nuchal translucency (NT) examination. PT and NBL values were expressed in multiples of the gestation-specific normal median (MoM) and as the PT/NBL ratio. Information on PT and NBL MoMs was also combined using logistic regression. Results were classified as positive according to whether they were greater than the normal 95th centile for PT, PT/NBL and the DS risk from logistic regression equation or below the 5th centile for NBL.
RESULTS
The median value in DS cases and unaffected controls were: PT 1.26 and 0.996 MoM; and NBL 0.596 and 0.993 MoM. The proportion of DS fetuses with positive results was 41% for PT, 65% for NBL, and 82% for both the PT/NBL ratio and DS risk from the logistic regression equation. PT/NBL levels did not vary according to gestational age.
CONCLUSION
The PT/NBL ratio is a valuable first trimester DS screening marker that can be easily determined concomitant with the NT measurement.
To perform a multicenter prospective study of ultrasound prenasal thickness (PT), and nasal bone length (NBL) measurement at 11-14 weeks' gestation.
METHODS
Ultrasound PT and NBL determination was performed in 504 normal fetuses and 17 fetuses with Down's syndrome (DS). Measurements were made from mid-sagittal 2D images acquired using a standardized technique during nuchal translucency (NT) examination. PT and NBL values were expressed in multiples of the gestation-specific normal median (MoM) and as the PT/NBL ratio. Information on PT and NBL MoMs was also combined using logistic regression. Results were classified as positive according to whether they were greater than the normal 95th centile for PT, PT/NBL and the DS risk from logistic regression equation or below the 5th centile for NBL.
RESULTS
The median value in DS cases and unaffected controls were: PT 1.26 and 0.996 MoM; and NBL 0.596 and 0.993 MoM. The proportion of DS fetuses with positive results was 41% for PT, 65% for NBL, and 82% for both the PT/NBL ratio and DS risk from the logistic regression equation. PT/NBL levels did not vary according to gestational age.
CONCLUSION
The PT/NBL ratio is a valuable first trimester DS screening marker that can be easily determined concomitant with the NT measurement.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s00404-019-05083-2
- PMID 30739175
- Persistent URL
- https://sonar.ch/global/documents/202685
Statistics
Document views: 28
File downloads: