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Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014.

  • Potron A Department of Bacteriology, University Hospital of Besançon, Université of Franche-Comté, Besançon, France.
  • Bernabeu S Joint Research Unit EERA "Evolution and Ecology of Resistance to Antibiotics," Institut Pasteur-APHP-Université Paris-Sud, Paris, France.
  • Cuzon G Joint Research Unit EERA "Evolution and Ecology of Resistance to Antibiotics," Institut Pasteur-APHP-Université Paris-Sud, Paris, France.
  • Pontiès V Santé Publique France, The French Public Health Agency, Saint-Maurice, France.
  • Blanchard H Regional Coordinating Centre for Nosocomial Infection Control (C-CLIN Paris Nord), Paris, France.
  • Seringe E Regional Coordinating Centre for Nosocomial Infection Control (C-CLIN Paris Nord), Paris, France.
  • Naas T Joint Research Unit EERA "Evolution and Ecology of Resistance to Antibiotics," Institut Pasteur-APHP-Université Paris-Sud, Paris, France.
  • Nordmann P Institute for Microbiology, University hospital and University of Lausanne, Lausanne, Switzerland.
  • Dortet L Joint Research Unit EERA "Evolution and Ecology of Resistance to Antibiotics," Institut Pasteur-APHP-Université Paris-Sud, Paris, France.
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  • 2017-12-14
Published in:
  • Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. - 2017
OXA-48-like
antibiotic resistance
carbapenems
endoscope
nosocomial
outbreak
Anti-Bacterial Agents
Endoscopes
Enterobacteriaceae
Enterobacteriaceae Infections
France
Humans
Multilocus Sequence Typing
Plasmids
Polymerase Chain Reaction
beta-Lactamases
English OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The blaOXA-204 gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/20370
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