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A β-Carbon elimination strategy for convenient in situ access to cyclopentadienyl metal complexes.
Journal article

A β-Carbon elimination strategy for convenient in situ access to cyclopentadienyl metal complexes.

  • Smits G Laboratory of Asymmetric Catalysis and Synthesis , EPFL SB ISIC LCSA , BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
  • Audic B Laboratory of Asymmetric Catalysis and Synthesis , EPFL SB ISIC LCSA , BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
  • Wodrich MD Laboratory for Computational Molecular Design , EPFL SB ISIC LCMD , BCH 5312 , CH-1015 Lausanne , Switzerland . Email: clemence.corminboeuf@epfl.ch.
  • Corminboeuf C Laboratory for Computational Molecular Design , EPFL SB ISIC LCMD , BCH 5312 , CH-1015 Lausanne , Switzerland . Email: clemence.corminboeuf@epfl.ch.
  • Cramer N Laboratory of Asymmetric Catalysis and Synthesis , EPFL SB ISIC LCSA , BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
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  • 2017-10-31
Published in:
  • Chemical science. - 2017
General Chemistry
English The electronic and steric properties of tailored cyclopentadienyl (Cp) ligands are powerful handles to modulate the catalytic properties of their metal complexes. This requires the individual preparation, purification and storage of each ligand/metal combination. Alternative, ideally in situ, complexation protocols would be of high utility. We disclose a new approach to access Cp metal complexes. Common metal precursors rapidly react with cyclopentadienyl carbinols via β-carbon eliminations to directly give the Cp-metal complexes. An advantage of this is the direct and flexible use of storable pre-ligands. No auxiliary base is required and the Cp complexes can be prepared in situ in the reaction vessel for subsequent catalytic transformations.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/204396
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