Journal article
Immune regulation by histamine.
- Jutel M Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland. marek.jutel@siaf.unizh.ch
- Watanabe T
- Akdis M
- Blaser K
- Akdis CA
- 2002-11-05
Published in:
- Current opinion in immunology. - 2002
Animals
Antibody Formation
Dendritic Cells
Histamine
Immune System
Mice
Monocytes
Receptors, Histamine
T-Lymphocytes
English
Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. In addition to its well-characterised effects in the acute inflammatory and allergic responses, histamine regulates several aspects of antigen-specific immune response development. Histamine affects the maturation of dendritic cells and alters their T cell-polarising capacity. Histamine also regulates antigen-specific T helper 1 and T helper 2 cells, as well as related antibody isotype responses. Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0952-7915(02)00395-3
- PMID 12413523
- Persistent URL
- https://sonar.ch/global/documents/204542
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