Back
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition.
Journal article

Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition.

  • Bissière S Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
  • Humeau Y
  • Lüthi A
  • 2003-05-13
Published in:
  • Nature neuroscience. - 2003
Amygdala
Animals
Conditioning, Psychological
Dopamine
Dopamine Agonists
Dopamine Antagonists
Excitatory Postsynaptic Potentials
Fear
GABA Antagonists
Interneurons
Learning
Long-Term Potentiation
Male
Mice
Mice, Inbred C57BL
Neural Inhibition
Neural Pathways
Organ Culture Techniques
Receptors, Dopamine
Synaptic Transmission
gamma-Aminobutyric Acid
English Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/204799
Statistics
Document views: 20 File downloads: