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Actin-related proteins in the nucleus: life beyond chromatin remodelers.
Journal article

Actin-related proteins in the nucleus: life beyond chromatin remodelers.

  • 2010-03-23
Published in:
  • Current opinion in cell biology. - 2010
Actins
Animals
Cell Nucleus
Chromatin Assembly and Disassembly
Humans
Models, Biological
Nuclear Proteins
Ribosomes
English Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/205354
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