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Different T cell receptor signals determine CD8+ memory versus effector development.
Journal article

Different T cell receptor signals determine CD8+ memory versus effector development.

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  • 2009-01-24
Published in:
  • Science (New York, N.Y.). - 2009
Adoptive Transfer
Animals
Antigen-Presenting Cells
CD8-Positive T-Lymphocytes
Cell Differentiation
Genes, T-Cell Receptor beta
Immunization
Immunologic Memory
Immunological Synapses
Listeria monocytogenes
Listeriosis
Lymphocyte Count
Mice
Mice, Transgenic
NF-kappa B
Point Mutation
Protein Structure, Tertiary
Receptors, Antigen, T-Cell, alpha-beta
Signal Transduction
T-Lymphocyte Subsets
English Following infection, naïve CD8+ T cells bearing pathogen-specific T cell receptors (TCRs) differentiate into a mixed population of short-lived effector and long-lived memory T cells to mediate an adaptive immune response. How the TCR regulates memory T cell development has remained elusive. Using a mutant TCR transgenic model, we found that point mutations in the TCR beta transmembrane domain (betaTMD) impair the development and function of CD8+ memory T cells without affecting primary effector T cell responses. Mutant T cells are deficient in polarizing the TCR and in organizing the nuclear factor kappaB signal at the immunological synapse. Thus, effector and memory states of CD8+ T cells are separable fates, determined by differential TCR signaling.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/205513
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