Journal article
Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock.
- Nobre V aIntensive Care, Switzerland bEmergency Department, University Hospitals of Geneva, Geneva, Switzerland.
- Sarasin FP
- Pugin J
- 2007-09-01
Published in:
- Current opinion in critical care. - 2007
Anti-Bacterial Agents
Cardiotonic Agents
Clinical Protocols
Critical Care
Dopamine
Drug Administration Schedule
Erythrocyte Transfusion
Fluid Therapy
Hemodynamics
Humans
Monitoring, Physiologic
Resuscitation
Sepsis
Shock, Septic
Time Factors
English
PURPOSE OF REVIEW
Treatment protocols targeting the rapid administration of appropriate antibiotics and hemodynamic support are now recognized as a key measure in the initial care of patients presenting with severe sepsis and septic shock. Strong evidence exists showing that time parameters, particularly in the emergency department, are as important as the nature of the treatment administered. The concept of sepsis bundles integrates evidence-based and time-sensitive issues, derived from international sepsis guidelines, to ensure that all eligible patients receive the right treatment as early as possible.
RECENT FINDINGS
Several studies have demonstrated that patients resuscitated according to sepsis bundles had a significantly lower mortality.
SUMMARY
It seems logical that timely and protocolized treatment for patients presenting with severe sepsis and septic shock will impact on outcome. It remains to be shown, however, whether translating evidence into clinical practice will increase adherence to the bundles and positively impact on survival.
Treatment protocols targeting the rapid administration of appropriate antibiotics and hemodynamic support are now recognized as a key measure in the initial care of patients presenting with severe sepsis and septic shock. Strong evidence exists showing that time parameters, particularly in the emergency department, are as important as the nature of the treatment administered. The concept of sepsis bundles integrates evidence-based and time-sensitive issues, derived from international sepsis guidelines, to ensure that all eligible patients receive the right treatment as early as possible.
RECENT FINDINGS
Several studies have demonstrated that patients resuscitated according to sepsis bundles had a significantly lower mortality.
SUMMARY
It seems logical that timely and protocolized treatment for patients presenting with severe sepsis and septic shock will impact on outcome. It remains to be shown, however, whether translating evidence into clinical practice will increase adherence to the bundles and positively impact on survival.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/MCC.0b013e3282e7d8e1
- PMID 17762240
- Persistent URL
- https://sonar.ch/global/documents/205772
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