Journal article
Mycobacterium decipiens sp. nov., a new species closely related to the Mycobacterium tuberculosis complex.
- Brown-Elliott BA 1Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
- Simmer PJ 2Division of Medical Microbiology, Johns Hopkins Medical Institute, Baltimore, Maryland, USA.
- Trovato A 3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
- Hyle EP 4Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
- Droz S 5Institute for Infectious Diseases, University of Berne, Berne, Switzerland.
- Buckwalter SP 6Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
- Borroni E 3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
- Branda JA 7Department of Pathology, Massachusetts General Hospital, Boston, USA.
- Iana E 8Children's Clinic, Santa Maria della Misericordia, University Hospital, Udine, Italy.
- Mariottini A 9Diagnostic Genetics Unit, Careggi University Hospital, Firenze, Italy.
- Nelson J 10Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
- Matteelli A 11Department of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy.
- Toney NC 12Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
- Scarparo C 13Microbiology Unit, Santa Maria della Misericordia, University Hospital, Udine, Italy.
- de Man TJB 12Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
- Vasireddy R 1Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
- Gandhi RT 4Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
- Wengenack NL 6Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
- Cirillo DM 3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
- Wallace RJ 1Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
- Tortoli E 3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
- 2018-09-12
Published in:
- International journal of systematic and evolutionary microbiology. - 2018
Mycobacterium decipiens
Mycobacterium tuberculosis complex
average nucleotide identity
whole genome sequencing
Bacterial Typing Techniques
Base Composition
DNA, Bacterial
Humans
Italy
Mycobacterium
Mycobacterium Infections
Mycobacterium tuberculosis
Mycolic Acids
Phylogeny
RNA, Ribosomal, 16S
Sequence Analysis, DNA
Tuberculosis, Cutaneous
United States
English
Two mycobacterial strains with close similarity to the Mycobacterium tuberculosis complex (MTBC) were isolated from cutaneous lesions of patients in the USA and Italy. At the phenotypic level, similarities to the MTBC included slow growth rate, rough morphotype of the unpigmented colonies and nearly identical high-performance liquid chromatography profiles of mycolic acids. In contrast to the MTBC, the strains were niacin- and nitrate-negative, and catalase-positive both at 68 °C and in semi-quantitative tests. The clinical isolates were more closely related to M. tuberculosis than to any other known mycobacterium and scored positive with commercial DNA probes (Hologic AccuProbe M. tuberculosis). Both average nucleotide identity and genome-to-genome distance suggested the strains are different from the MTBC. Therefore, given the distinguishing phenotypic and genomic-scale differences, we submit that the strains belong to a new species we have named Mycobacteriumdecipiens with type strain TBL 1200985T (=ATCC TSD-117T=DSM 105360T).
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1099/ijsem.0.003031
- PMID 30204586
- Persistent URL
- https://sonar.ch/global/documents/206104
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