Journal article
Three weeks of sprint interval training improved high-intensity cycling performance and limited ryanodine receptor modifications in recreationally active human subjects.
- Schlittler M Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
- Neyroud D Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015, Lausanne, Switzerland.
- Tanga C Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015, Lausanne, Switzerland.
- Zanou N Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015, Lausanne, Switzerland.
- Kamandulis S Sports Science and Innovation Institute, Lithuanian Sports University, Kaunas, Lithuania.
- Skurvydas A Sports Science and Innovation Institute, Lithuanian Sports University, Kaunas, Lithuania.
- Kayser B Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015, Lausanne, Switzerland.
- Westerblad H Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
- Place N Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015, Lausanne, Switzerland. nicolas.place@unil.ch.
- Andersson DC Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
- 2019-06-29
Published in:
- European journal of applied physiology. - 2019
Physical exercise
Ryanodine receptor 1
Skeletal muscle
Sprint interval training
Adaptation, Physiological
Adult
Exercise
Exercise Test
High-Intensity Interval Training
Humans
Male
Muscle, Skeletal
Oxygen Consumption
Physical Endurance
Ryanodine Receptor Calcium Release Channel
Young Adult
English
PURPOSE
Mechanisms underlying the efficacy of sprint interval training (SIT) remain to be understood. We previously reported that an acute bout of SIT disrupts the integrity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor 1 (RyR1), in recreationally active human subjects. We here hypothesize that in addition to improving the exercise performance of recreationally active humans, a period of repeated SIT sessions would make the RyR1 protein less vulnerable and accelerate recovery of contractile function after a SIT session.
METHODS
Eight recreationally active males participated in a 3-week SIT program consisting of nine sessions of four-six 30-s all-out cycling bouts with 4 min of rest between bouts.
RESULTS
Total work performed during a SIT session and maximal power (Wmax) reached during an incremental cycling test were both increased by ~ 7.5% at the end of the training period (P < 0.05). Western blots performed on vastus lateralis muscle biopsies taken before, 1 h, 24 h and 72 h after SIT sessions in the untrained and trained state showed some protection against SIT-induced reduction of full-length RyR1 protein expression in the trained state. SIT-induced knee extensor force deficits were similar in the untrained and trained states, with a major reduction in voluntary and electrically evoked forces immediately and 1 h after SIT (P < 0.05), and recovery after 24 h.
CONCLUSIONS
Three weeks of SIT improves exercise performance and provides some protection against RyR1 modification, whereas it does not accelerate recovery of contractile function.
Mechanisms underlying the efficacy of sprint interval training (SIT) remain to be understood. We previously reported that an acute bout of SIT disrupts the integrity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor 1 (RyR1), in recreationally active human subjects. We here hypothesize that in addition to improving the exercise performance of recreationally active humans, a period of repeated SIT sessions would make the RyR1 protein less vulnerable and accelerate recovery of contractile function after a SIT session.
METHODS
Eight recreationally active males participated in a 3-week SIT program consisting of nine sessions of four-six 30-s all-out cycling bouts with 4 min of rest between bouts.
RESULTS
Total work performed during a SIT session and maximal power (Wmax) reached during an incremental cycling test were both increased by ~ 7.5% at the end of the training period (P < 0.05). Western blots performed on vastus lateralis muscle biopsies taken before, 1 h, 24 h and 72 h after SIT sessions in the untrained and trained state showed some protection against SIT-induced reduction of full-length RyR1 protein expression in the trained state. SIT-induced knee extensor force deficits were similar in the untrained and trained states, with a major reduction in voluntary and electrically evoked forces immediately and 1 h after SIT (P < 0.05), and recovery after 24 h.
CONCLUSIONS
Three weeks of SIT improves exercise performance and provides some protection against RyR1 modification, whereas it does not accelerate recovery of contractile function.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s00421-019-04183-w
- PMID 31250088
- Persistent URL
- https://sonar.ch/global/documents/20631
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