Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients.
Journal article

Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients.

  • Dietmann A Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland. Electronic address: anelia.dietmann@insel.com.
  • Horn MP Department of Clinical Chemistry, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
  • Schinkelshoek MS Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Sleep-wake Centre SEIN, Heemstede, the Netherlands.
  • Fronczek R Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Sleep-wake Centre SEIN, Heemstede, the Netherlands.
  • Salmen A Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
  • Bargiotas P Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
  • Lammers GJ Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Sleep-wake Centre SEIN, Heemstede, the Netherlands.
  • Khatami R Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland; Center for Sleep Medicine and Sleep Research, Clinic Barmelweid, Barmelweid, Switzerland.
  • Bassetti CLA Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland; Neurology Department, Sechenov First Moscow State Medical University, Moscow, Russia.
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  • 2020-08-29
Published in:
  • Sleep medicine. - 2020
English Narcolepsy with cataplexy (NT1) is a chronic hypothalamic disorder with a presumed immune-mediated etiology leading to a loss of hypocretin neurons. Previous studies reported conflicting results in terms of presence of auto-antibodies involved in narcolepsy pathophysiology. A total of 86 patients with primary/idiopathic narcolepsy (74 NT1, 12 NT2) and 23 control patients with excessive daytime sleepiness due to other causes were tested for the presence of a wide range of anti-neuronal antibodies in both serum and cerebrospinal fluid (CSF). Anti-neuronal antibodies were rarely found in patients with narcolepsy (n = 2) and in controls (n = 1). Our results are in line with previous reports. We can therefore support the current evidence, that conventional anti-neuronal antibodies are not routinely detected during the workup of NT1 and other CDH patients.
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  • English
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closed
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https://sonar.ch/global/documents/208022
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