Journal article
Mechanical force induces mitochondrial fission
- Helle, Sebastian Carsten Johannes Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
- Feng, Qian Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
- Aebersold, Mathias J Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland
- Hirt, Luca Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland
- Grüter, Raphael R Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland
- Vahid, Afshin ORCID Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands
- Sirianni, Andrea Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom
- Mostowy, Serge Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom
- Snedeker, Jess G Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
- Šarić, Anđela ORCID Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, United Kingdom
- Idema, Timon ORCID Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands
- Zambelli, Tomaso Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland
- Kornmann, Benoît ORCID Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
- 2017-11-9
Published in:
- eLife. - eLife Sciences Publications, Ltd. - 2017, vol. 6
English
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria – via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces – results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.7554/elife.30292
- ISSN 2050-084X
- Persistent URL
- https://sonar.ch/global/documents/208581
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