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Physiological responses of carp (Cyprinus carpio L.) to dietary exposure to zearalenone (ZEN).

  • Pietsch C Zurich University of Applied Sciences (ZHAW), Institute of Natural Resource Sciences (IUNR), Gruental, P.O. Box, CH-8820 Waedenswil, Switzerland. Electronic address: constanze.pietsch@zhaw.ch.
  • Junge R Zurich University of Applied Sciences (ZHAW), Institute of Natural Resource Sciences (IUNR), Gruental, P.O. Box, CH-8820 Waedenswil, Switzerland.
  • 2016-06-29
Published in:
  • Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. - 2016
Aquaculture
Carp
Metabolic costs
Mycotoxin
Physiological stress
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Biomarkers
Carps
Dose-Response Relationship, Drug
Energy Metabolism
Food Contamination
Kidney
Lipid Peroxidation
Liver
Muscles
Oxygen Consumption
Risk Assessment
Spleen
Time Factors
Zearalenone
English Zearalenone (ZEN) is a frequent contaminant of animal feeds, but systemic effects on fish and possible metabolic costs have not yet been investigated. In order to fill this gap a feeding trial with juvenile carp was conducted. The fish were fed ZEN-contaminated diets at three concentrations (low: 332μgkg(-1), medium: 621μgkg(-1), and high: 797μgkg(-1) final feed, respectively) for four weeks. Possible reversible effects of ZEN were evaluated by feeding an additional group with the mycotoxin for four weeks period and the uncontaminated diet for further two weeks. After that possible ZEN effects on enzyme activities in kidney, spleen, liver and muscle tissue were investigated to get an organism-wide aspect of ZEN effects. Most organs appeared to (over)compensate ZEN effects during the exposure to this mycotoxin, which caused metabolic costs. Oxygen consumption increased in fish treated with the two higher ZEN concentrations via the diet. The differences between the treatments persisted also after the recovery phase of two weeks. Thus, the present study provided evidence of effects of ZEN on carbohydrate metabolism, lipid peroxidation in organs and metabolic oxygen demand. This is the first evidence for increased metabolic costs in a fish species due to exposure to the mycotoxin ZEN.
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  • English
Open access status
green
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https://sonar.ch/global/documents/208816
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