Bioorthogonal chemistry in bioluminescence imaging.

Godinat A; Bazhin AA; Goun EA

doi:10.1016/j.drudis.2018.05.022

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Journal article

Bioorthogonal chemistry in bioluminescence imaging.

Godinat A Institute of Chemical Biology, Department of Chemistry, Imperial College London, London SW7 2AZ, UK.
Bazhin AA Laboratory of Bioorganic Chemistry and Molecular Imaging, Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.
Goun EA Laboratory of Bioorganic Chemistry and Molecular Imaging, Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: elena.goun@epfl.ch.

2018-05-21

Published in:

Drug discovery today. - 2018

Chemistry Techniques, Synthetic

English Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we review bioorthogonal reactions that have been used to signific antly broaden the application range of BLI.

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