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G-protein-independent signaling by G-protein-coupled receptors.
Journal article

G-protein-independent signaling by G-protein-coupled receptors.

  • Heuss C Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Gerber U
  • 2000-09-28
Published in:
  • Trends in neurosciences. - 2000
Animals
Gene Expression Regulation
Heterotrimeric GTP-Binding Proteins
Humans
Invertebrates
MAP Kinase Signaling System
Models, Neurological
Nerve Tissue Proteins
Neurotransmitter Agents
Receptor Protein-Tyrosine Kinases
Receptors, Growth Factor
Receptors, Metabotropic Glutamate
Receptors, Neurotransmitter
Signal Transduction
Synaptic Transmission
Transcriptional Activation
Vertebrates
src-Family Kinases
English Two classes of receptors transduce neurotransmitter signals: ionotropic receptors and heptahelical metabotropic receptors. Whereas the ionotropic receptors are structurally associated with a membrane channel, a mediating mechanism is necessary to functionally link metabotropic receptors with their respective effectors. According to the accepted paradigm, the first step in the metabotropic transduction process requires the activation of heterotrimeric G-proteins. An increasing number of observations, however, point to a novel mechanism through which neurotransmitters can initiate biochemical signals and modulate neuronal excitability. According to this mechanism metabotropic receptors induce responses by activating transduction systems that do not involve G-proteins.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/210499
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