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The galactosyltransferase family.
Journal article

The galactosyltransferase family.

  • Hennet T Institute of Physiology, University of Zürich, Switzerland. thennet@access.unizh.ch
  • 2002-09-12
Published in:
  • Cellular and molecular life sciences : CMLS. - 2002
Amino Acid Sequence
Animals
Bacteria
Carbohydrate Sequence
Galactosyltransferases
Glycoconjugates
Molecular Sequence Data
Phylogeny
Sequence Alignment
Substrate Specificity
English Galactose is transferred via several linkages to acceptor structures by galactosyltransferase enzymes. In prokaryotes, galactose is mainly found on lipopolysaccharides and capsular polysaccharides. In eukaryotes, galactosyltransferases, which are localized in the Golgi apparatus, are involved in the formation of several classes of glycoconjugates and in lactose biosynthesis. Although they sometimes catalyze identical reactions, prokaryotic and eukaryotic galactosyltransferases share only little structural similarities. In mammals, 19 distinct galactosyltransferase enzymes have been characterized to date. These enzymes catalyze the transfer of galactose via beta1-4, beta1-3, alpha1-3 and alpha1-4 linkages. The present review focuses on the description of these mammalian galactosyltransferases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/210584
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