Journal article
Nogo and axon regeneration.
- Schwab ME Brain Research Institute University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland. schwab@hifo.unizh.ch
- 2004-03-17
Published in:
- Current opinion in neurobiology. - 2004
English
Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the postreceptor components Rho-A and ROCK induce long-distance axonal regeneration and compensatory sprouting, accompanied by an impressive enhancement of functional recovery, in the rat and mouse spinal cord.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.conb.2004.01.004
- PMID 15018947
- Persistent URL
- https://sonar.ch/global/documents/210739
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