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The hypertension peril: lessons from CETP inhibitors.
Journal article

The hypertension peril: lessons from CETP inhibitors.

  • Hermann M Department of Cardiology, University Hospital Zürich Ramistrasse 100, Zürich, Switzerland. mhermann@gmx.de
  • Ruschitzka FT
  • 2009-01-17
Published in:
  • Current hypertension reports. - 2009
Anticholesteremic Agents
Cholesterol Ester Transfer Proteins
Dyslipidemias
Humans
Hypertension
Quinolines
English Pharmacologic inhibitors of the cholesteryl ester transfer protein (CETP) are capable of increasing HDL cholesterol by 50% to 100% in humans. Despite intriguing antiatherogenic effects of CETP inhibition in animal models of atherosclerosis, the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial investigators observed an excess of cardiovascular and noncardiovascular morbidity and mortality associated with the use of the CETP inhibitor torcetrapib. This review summarizes available clinical and experimental data about potential underlying mechanisms.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/210893
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