Journal article
Granzyme a, a stealth killer in the mitochondrion.
- Lucken-Ardjomande S Department of Cell Biology, University of Geneva, 30 quai Ernest-Ansermet, Geneva CH-1211, Switzerland.
- Martinou JC
- 2008-05-20
Published in:
- Cell. - 2008
Animals
Cell Death
Granzymes
Humans
Membrane Potential, Mitochondrial
Mitochondria
NADH Dehydrogenase
Protein Transport
Reactive Oxygen Species
T-Lymphocytes, Cytotoxic
English
The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain) leading to production of reactive oxygen species and ultimately to cell death.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.cell.2008.04.031
- PMID 18485862
- Persistent URL
- https://sonar.ch/global/documents/21096
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