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Interfacial Structure and Hydration of 3D Lipid Monolayers in Aqueous Solution.
Journal article

Interfacial Structure and Hydration of 3D Lipid Monolayers in Aqueous Solution.

  • Okur HI Laboratory for Fundamental BioPhotonics (LBP), Institute of Bioengineering (IBI), and Institute of Materials Science (IMX), School of Engineering (STI), and Lausanne Centre for Ultrafast Science (LACUS), École Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.
  • Chen Y Laboratory for Fundamental BioPhotonics (LBP), Institute of Bioengineering (IBI), and Institute of Materials Science (IMX), School of Engineering (STI), and Lausanne Centre for Ultrafast Science (LACUS), École Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.
  • Smolentsev N Laboratory for Fundamental BioPhotonics (LBP), Institute of Bioengineering (IBI), and Institute of Materials Science (IMX), School of Engineering (STI), and Lausanne Centre for Ultrafast Science (LACUS), École Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.
  • Zdrali E Laboratory for Fundamental BioPhotonics (LBP), Institute of Bioengineering (IBI), and Institute of Materials Science (IMX), School of Engineering (STI), and Lausanne Centre for Ultrafast Science (LACUS), École Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.
  • Roke S Laboratory for Fundamental BioPhotonics (LBP), Institute of Bioengineering (IBI), and Institute of Materials Science (IMX), School of Engineering (STI), and Lausanne Centre for Ultrafast Science (LACUS), École Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.
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  • 2017-03-07
Published in:
  • The journal of physical chemistry. B. - 2017
Hydrophobic and Hydrophilic Interactions
Lipids
Molecular Structure
Solutions
Water
English Three-dimensional (3D) phospholipid monolayers at hydrophobic surfaces are ubiquitous and found in nature as adiposome organelles or in man-made materials such as drug delivery systems. However, the molecular level understanding of such monolayers remains elusive. Here, we investigate the molecular structure of phosphatidylcholine (PC) lipids forming 3D monolayers on the surface of hexadecane nanodroplets. The effects of acyl chain length, saturation, and number of acyl tails per lipid were studied with vibrational sum frequency and second harmonic scattering techniques. We find that 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) lipids form tightly packed monolayers. Upon shortening the tail length to 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), more gauche defects are observed. Monolayers of unsaturated 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and single acyl chained 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (lyso-PC) contain more disorder. Despite these variations in the packing, the headgroup orientation remained approximately parallel to the nanodroplet interface. Remarkably, the lyso-PC uniquely forms more diluted and "patchy" 3D monolayers.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/211251
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