Back
Objective Morphological Classification of Neocortical Pyramidal Cells.
Journal article

Objective Morphological Classification of Neocortical Pyramidal Cells.

  • Kanari L Blue Brain Project, Brain and Mind Institute, EPFL, Campus Biotech: CH 1202, Geneva, Switzerland.
  • Ramaswamy S Blue Brain Project, Brain and Mind Institute, EPFL, Campus Biotech: CH 1202, Geneva, Switzerland.
  • Shi Y Blue Brain Project, Brain and Mind Institute, EPFL, Campus Biotech: CH 1202, Geneva, Switzerland.
  • Morand S Laboratory for Topology and Neuroscience, Brain Mind Institute, EPFL, CH 1015, Lausanne, Switzerland.
  • Meystre J Laboratory of Neural Microcircuitry, Brain Mind Institute, EPFL, CH 1015, Lausanne, Switzerland.
  • Perin R Laboratory of Neural Microcircuitry, Brain Mind Institute, EPFL, CH 1015, Lausanne, Switzerland.
  • Abdellah M Blue Brain Project, Brain and Mind Institute, EPFL, Campus Biotech: CH 1202, Geneva, Switzerland.
  • Wang Y School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou, Zhejiang, PR China.
  • Hess K Laboratory for Topology and Neuroscience, Brain Mind Institute, EPFL, CH 1015, Lausanne, Switzerland.
  • Markram H Blue Brain Project, Brain and Mind Institute, EPFL, Campus Biotech: CH 1202, Geneva, Switzerland.
Show more…
  • 2019-02-05
Published in:
  • Cerebral cortex (New York, N.Y. : 1991). - 2019
neuronal classification
neuronal morphology
pyramidal cells
rat somatosensory cortex
topological data analysis
Animals
Imaging, Three-Dimensional
Lysine
Neocortex
Pattern Recognition, Automated
Pyramidal Cells
Rats
Somatosensory Cortex
Supervised Machine Learning
English A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies. Even for neurons that are visually distinguishable, there is no common ground to consistently define morphological types. The objective classification of PCs can be achieved with methods from algebraic topology, and the dendritic arborization is sufficient for the reliable identification of distinct types of cortical PCs. Therefore, we objectively identify 17 types of PCs in the rat somatosensory cortex. In addition, we provide a solution to the challenging problem of whether 2 similar neurons belong to different types or to a continuum of the same type. Our topological classification does not require expert input, is stable, and helps settle the long-standing debate on whether cell-types are discrete or continuous morphological variations of each other.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/211427
Statistics
Document views: 61 File downloads: