Inflammatory cytokines in pulmonary hypertension.
- Groth A Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland. lars.huber@usz.ch.
- Vrugt B
- Brock M
- Speich R
- Ulrich S
- Huber LC
- 2014-04-18
Published in:
- Respiratory research. - 2014
English
Pulmonary hypertension is an "umbrella term" used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension.This review summarizes the latest clinical and experimental developments in inflammation associated with pulmonary hypertension with special focus on Interleukin-6, and its role in vascular remodeling in pulmonary hypertension.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1186/1465-9921-15-47
- PMID 24739042
- Persistent URL
- https://sonar.ch/global/documents/211923
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