Animal models of Epstein Barr virus infection.
- Gujer C Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
- Chatterjee B Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
- Landtwing V Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
- Raykova A Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
- McHugh D Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
- Münz C Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland. Electronic address: christian.muenz@uzh.ch.
- 2015-04-08
Published in:
- Current opinion in virology. - 2015
Animals
Disease Models, Animal
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Humans
Mice
T-Lymphocytes
English
Epstein Barr virus (EBV) was the first human tumor virus to be described. Despite its discovery now more than fifty years ago, immune control of this virus is still not very well understood and no vaccine is available. This knowledge gap is due in part to the lack of a preclinical small animal model which can faithfully recapitulate EBV infection and immune control, and would allow testing of EBV specific vaccine candidates. With the advent of mice with reconstituted human immune system compartments (HIS mice) during the past decade this is changing. We will discuss which aspects of EBV infection and its immune control can already be modeled in HIS mice, and which shortcomings still need to be overcome in order to recapitulate the immunobiology of oncogenic EBV infection.
- Language
-
- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.coviro.2015.03.014
- PMID 25846986
- Persistent URL
- https://sonar.ch/global/documents/211996
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