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Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS.
Journal article

Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS.

  • Binz TM University of Zurich, Zurich Institute of Forensic Medicine, Center for Forensic Hairanalytics, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland.
  • Yegles M Laboratoire National de Santé, Service de Toxicologie, 1 rue Louis Rech, L-3555 Dudelange, Luxembourg.
  • Schneider S Laboratoire National de Santé, Service de Toxicologie, 1 rue Louis Rech, L-3555 Dudelange, Luxembourg.
  • Neels H Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
  • Crunelle CL Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. Electronic address: cleo.crunelle@gmail.com.
  • 2014-07-30
Published in:
  • Forensic science international. - 2014
7-OH-quetiapine
Antipsychotics
Hair analysis
LC–MS/MS
Quetiapine
Adult
Antipsychotic Agents
Chromatography, Liquid
Dibenzothiazepines
Female
Hair
Humans
Limit of Detection
Male
Middle Aged
Quetiapine Fumarate
Tandem Mass Spectrometry
Time Factors
English Hair analysis is a powerful tool for retrospective drug analysis and has a wide application window. This article describes the simultaneous determination and quantification of the short-acting atypical antipsychotic drug quetiapine and its main metabolite 7-OH quetiapine in hair. A sensitive and accurate method for the determination of these two compounds was developed using high-performance liquid chromatography coupled to tandem mass spectrometry detection (LC-MS/MS). The method was applied to 10 real case samples. For five patients, a time resolved hair analysis was done. Results varied from 0.35 ng/mg to 10.21 ng/mg hair for quetiapine and from 0.02 ng/mg to 3.19 ng/mg hair for 7-OH-quetiapine.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/212041
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