Back
Ni-catalyzed Sonogashira coupling of nonactivated alkyl halides: orthogonal functionalization of alkyl iodides, bromides, and chlorides.
Journal article

Ni-catalyzed Sonogashira coupling of nonactivated alkyl halides: orthogonal functionalization of alkyl iodides, bromides, and chlorides.

  • Vechorkin O Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, SB-ISIC-LSCI, BCH 3305, Lausanne CH 1015, Switzerland.
  • Barmaz D
  • Proust V
  • Hu X
  • 2009-08-13
Published in:
  • Journal of the American Chemical Society. - 2009
Alkanes
Bromine
Catalysis
Chlorine
Halogens
Iodine
Nickel
English Ni-catalyzed Sonogashira coupling of nonactivated, beta-H-containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl halide, in both coupling partners. The coupling can be selective for a specific C-X bond (X = I, Br, Cl) and allows for orthogonal functionalization of alkyl halides with multiple reactive sites.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/212132
Statistics
Document views: 30 File downloads: