Effect of methylene blue on the disposition of ethanol.
- Vonlanthen R Department of Medicine, Kantonsspital Baden, Bern, Switzerland.
- Beer JH
- Lauterburg BH
- 2000-10-07
Published in:
- Alcohol and alcoholism (Oxford, Oxfordshire). - 2000
Adult
Animals
Central Nervous System Depressants
Enzyme Inhibitors
Ethanol
Hepatocytes
Humans
Lactic Acid
Male
Methylene Blue
Pyruvic Acid
Rats
Rats, Sprague-Dawley
English
The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1093/alcalc/35.5.424
- PMID 11022014
- Persistent URL
- https://sonar.ch/global/documents/212458
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