Effect of methylene blue on the disposition of ethanol.

Vonlanthen R; Beer JH; Lauterburg BH

doi:10.1093/alcalc/35.5.424

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Journal article

Effect of methylene blue on the disposition of ethanol.

Vonlanthen R Department of Medicine, Kantonsspital Baden, Bern, Switzerland.
Beer JH
Lauterburg BH

2000-10-07

Published in:

Alcohol and alcoholism (Oxford, Oxfordshire). - 2000

Central Nervous System Depressants

English The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.

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