Role and regulation of RUNX2 in osteogenesis.
- Bruderer M AO Research Institute Davos, Clavadelerstrasse 8, CH-7270 Davos Platz, Switzerland.martin.stoddart@aofoundation.org.
- Richards RG
- Alini M
- Stoddart MJ
- 2014-10-24
Published in:
- European cells & materials. - 2014
Animals
Core Binding Factor Alpha 1 Subunit
Gene Expression Regulation, Developmental
Humans
Osteoblasts
Osteogenesis
English
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.22203/ecm.v028a19
- PMID 25340806
- Persistent URL
- https://sonar.ch/global/documents/212653
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