GABA neurons of the VTA drive conditioned place aversion.
- Tan KR Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland.
- Yvon C
- Turiault M
- Mirzabekov JJ
- Doehner J
- Labouèbe G
- Deisseroth K
- Tye KM
- Lüscher C
- 2012-03-27
Published in:
- Neuron. - 2012
Action Potentials
Analgesics, Opioid
Analysis of Variance
Animals
Apomorphine
Bacterial Proteins
Channelrhodopsins
Conditioning, Operant
Dopamine Agonists
Dopamine Antagonists
Dopaminergic Neurons
Electroshock
Escape Reaction
G Protein-Coupled Inwardly-Rectifying Potassium Channels
GABAergic Neurons
Glutamate Decarboxylase
Haloperidol
In Vitro Techniques
Luminescent Proteins
Mice
Mice, Inbred C57BL
Mice, Transgenic
Morphine
Optics and Photonics
Time Factors
Tyrosine 3-Monooxygenase
Ventral Tegmental Area
English
Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
- Language
-
- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.neuron.2012.02.015
- PMID 22445344
- Persistent URL
- https://sonar.ch/global/documents/21374
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