Potential in vivo transfer of a blaCTX-M14-harbouring plasmid established by combining long- and short-read sequencing.
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Xavier BB
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.
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Renzi G
Clinical Microbiology Laboratory, University of Geneva Hospitals, Faculty of Medicine, Geneva, Switzerland.
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Lammens C
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.
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Cherkaoui A
Clinical Microbiology Laboratory, University of Geneva Hospitals, Faculty of Medicine, Geneva, Switzerland.
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Goossens H
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.
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Schrenzel J
Clinical Microbiology Laboratory, University of Geneva Hospitals, Faculty of Medicine, Geneva, Switzerland.
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Harbarth S
Infection Control Program, University of Geneva Hospitals, Faculty of Medicine, Geneva, Switzerland.
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Malhotra-Kumar S
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium. Electronic address: surbhi.malhotra@uantwerpen.be.
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Published in:
- Journal of microbiological methods. - 2019
English
Horizontal transfer of plasmid-mediated antibiotic resistance has rarely been documented in vivo. Utilizing long-read (Oxford Nanopore) and short-read (Illumina) sequencing, we confirmed that a gut-colonizing Escherichia coli and a hypervirulent Klebsiella pneumoniae ST23, isolated from a surgical site culture of a patient receiving cefuroxime therapy, harboured a 100% identical blaCTX-M-14-harbouring plasmid, indicative of a potential transfer in vivo.
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green
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https://sonar.ch/global/documents/213812
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