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Structure-property relationships of trimetazidine derivatives and model compounds as potential antioxidants.
Journal article

Structure-property relationships of trimetazidine derivatives and model compounds as potential antioxidants.

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  • 1998-07-09
Published in:
  • Free radical biology & medicine. - 1998
Antioxidants
Bepridil
Biphenyl Compounds
Computer Simulation
Cresols
Free Radical Scavengers
Free Radicals
Hydroquinones
Models, Chemical
Phenols
Picrates
Structure-Activity Relationship
Trimetazidine
Vitamin E
English Twenty-five compounds (trimetazidine derivatives and other compounds, mostly having a free phenolic group) were examined for their radical scavenging and antioxidant properties. Their reaction with DPPH (2,2-diphenyl-1-picrylhydrazyl) as a measure of radical scavenging capacity was assessed by two parameters, namely EC50 (the concentration of antioxidant decreasing DPPH by 50%), and log Z, a kinetic parameter proposed here and derived from initial second-order rate constants and antioxidant/DPPH ratios. Antioxidant activities were determined by the inhibition of lipid peroxidation and albumin oxidation. The most active compounds were derivatives having a trolox or hydroquinone moiety. Physicochemical and structural properties were determined by molecular modeling as lipophilicity (virtual log P calculations) and H-Surf (solvent-accessible surface of hydroxyl hydrogen) and by quantum mechanical calculations (deltaH(ox) = oxidation enthalpy; deltaH(abs) = enthalpy of hydrogen abstraction). QSAR models were derived to identify molecular mechanisms responsible for the reactivity toward the DPPH radical and for the inhibition of lipid peroxidation. A useful prediction of antioxidant capacity could be achieved from calculated molecular properties and the kinetic parameter developed here.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/2139
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