Journal article
Comparing dynamic susceptibility contrast perfusion post-processing with different clinically available software among patients affected of a high-grade glioma.
- Delacoste EL HES-SO Master Conjoint Avec l'UNIL, Avenue de Provence 6, 1007 Lausanne Vaud, Suisse. Electronic address: eloise.delacoste@hcuge.ch.
- Delattre BMA Unité de Neuroradiologie Diagnostique, Hôpitaux Universitaires de Genève, Faculté de Médecine de Genève, Rue Gabrielle-Perret-Gentil 4, 1205 Genève, Suisse. Electronic address: benedicte.delattre@hcuge.ch.
- Wanyanga P Hôpital Fribourgeois, Chemin des Pensionnats 2-6, 1752 Villars-sur-Glâne, Vaud, Suisse. Electronic address: w.pierre.m@gmail.com.
- Vargas MI Unité de Neuroradiologie Diagnostique, Hôpitaux Universitaires de Genève, Faculté de Médecine de Genève, Rue Gabrielle-Perret-Gentil 4, 1205 Genève, Suisse. Electronic address: maria.i.vargas@hcuge.ch.
- 2020-10-16
Published in:
- Journal of neuroradiology = Journal de neuroradiologie. - 2020
Dynamic susceptibility contrast perfusion
High-grade glioma
MRI
Post-processing software
Reproducibility
English
BACKGROUND AND PURPOSE
The main purpose of this retrospective study was to evaluate inter-software variability in patients affected of a high-grade glioma for the post-processing of dynamic susceptibility contrast (DSC1) perfusion imaging in MRI.2 MATERIALS AND METHODS: The included patients were either anaplastic astrocytoma (WHO3 grade III) or glioblastoma (WHO grade IV) located in the cerebral parenchyma. The postprocessing of 54 MRI-DSC imaging from 46 patients using both Intellispace© (Philips) and Olea© (Olea Medical) software was performed. The hemodynamic parameter studied was the normalised relative cerebral blood volume corrected for the T1 leakage effect (nrCBVc4). The inter-operator variabilities were also evaluated.
RESULTS
Regarding inter-software reproducibility, Cohen's Kappa from therapeutic follow-up obtained were 0.61, close to the recommended limit (0.60). Subgroups were created to complete the analysis and to evaluate the partial volume effect. Even if necrosis or vascular structures from regions of interest (ROI5) were avoided, results did not improve. ROI of a minimum area of 250 mm2 yielded a Cohen's Kappa of 0.65. The inter-operator reproducibility on Intellispace and Olea were 0.90 and 0.73 respectively, which is satisfactory.
CONCLUSION
The reproducibility between Intellispace and Olea was below recommended threshold in a clinical context. This discrepancy can be explained by the partial volume effect and the models used. ROI with an area of at least 250 mm2 improves this reproducibility and becomes acceptable.
The main purpose of this retrospective study was to evaluate inter-software variability in patients affected of a high-grade glioma for the post-processing of dynamic susceptibility contrast (DSC1) perfusion imaging in MRI.2 MATERIALS AND METHODS: The included patients were either anaplastic astrocytoma (WHO3 grade III) or glioblastoma (WHO grade IV) located in the cerebral parenchyma. The postprocessing of 54 MRI-DSC imaging from 46 patients using both Intellispace© (Philips) and Olea© (Olea Medical) software was performed. The hemodynamic parameter studied was the normalised relative cerebral blood volume corrected for the T1 leakage effect (nrCBVc4). The inter-operator variabilities were also evaluated.
RESULTS
Regarding inter-software reproducibility, Cohen's Kappa from therapeutic follow-up obtained were 0.61, close to the recommended limit (0.60). Subgroups were created to complete the analysis and to evaluate the partial volume effect. Even if necrosis or vascular structures from regions of interest (ROI5) were avoided, results did not improve. ROI of a minimum area of 250 mm2 yielded a Cohen's Kappa of 0.65. The inter-operator reproducibility on Intellispace and Olea were 0.90 and 0.73 respectively, which is satisfactory.
CONCLUSION
The reproducibility between Intellispace and Olea was below recommended threshold in a clinical context. This discrepancy can be explained by the partial volume effect and the models used. ROI with an area of at least 250 mm2 improves this reproducibility and becomes acceptable.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.neurad.2020.09.010
- PMID 33065197
- Persistent URL
- https://sonar.ch/global/documents/213986
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