Back
The chemokine receptor CCR5 in the central nervous system.
Journal article

The chemokine receptor CCR5 in the central nervous system.

  • Sorce S Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, 1211 Geneva-4, Switzerland.
  • Myburgh R
  • Krause KH
  • 2010-12-18
Published in:
  • Progress in neurobiology. - 2011
Animals
Cell Survival
Central Nervous System
HIV Infections
Humans
Models, Molecular
Neurons
Protein Isoforms
Receptors, CCR5
English The expression and the role of the chemokine receptor CCR5 have been mainly studied in the context of HIV infection. However, this protein is also expressed in the brain, where it can be crucial in determining the outcome in response to different insults. CCR5 expression can be deleterious or protective in controlling the progression of certain infections in the CNS, but it is also emerging that it could play a role in non-infectious diseases. In particular, it appears that, in addition to modulating immune responses, CCR5 can influence neuronal survival. Here, we summarize the present knowledge about the expression of CCR5 in the brain and highlight recent findings suggesting its possible involvement in neuroprotective mechanisms.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/214349
Statistics
Document views: 56 File downloads: