Alcohol use and depression: link with adherence and viral suppression in adult patients on antiretroviral therapy in rural Lesotho, Southern Africa: a cross-sectional study.
- Cerutti B Faculty of Medicine, University of Geneva, UDREM, 1 Rue Michel Servet, 1211, Geneva 4, Switzerland. bernard.cerutti@unige.ch.
- Broers B Dependencies Unit, Department of Community Medicine, Geneva University Hospitals, Geneva, Switzerland.
- Masetsibi M SolidarMed, Swiss Organization for Health in Africa, Maseru, Lesotho.
- Faturiyele O SolidarMed, Swiss Organization for Health in Africa, Maseru, Lesotho.
- Toti-Mokoteli L SolidarMed, Swiss Organization for Health in Africa, Maseru, Lesotho.
- Motlatsi M SolidarMed, Swiss Organization for Health in Africa, Maseru, Lesotho.
- Bader J Department of Biomedicine, University of Basel, Basel, Switzerland.
- Klimkait T Department of Biostatistics, Epidemiology and Public Health Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Labhardt ND Clinical Research Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
- 2016-09-10
Published in:
- BMC public health. - 2016
Africa
Alcohol
Depression
HIV, antiretroviral therapy
Medication adherence
Adult
Africa
Africa, Southern
Alcohol Abstinence
Alcohol Drinking
Alcoholism
Anti-Retroviral Agents
Cross-Sectional Studies
Depression
Female
HIV Infections
Humans
Lesotho
Male
Medication Adherence
Middle Aged
Odds Ratio
Prevalence
Rural Population
English
BACKGROUND
Depression and alcohol use disorder have been shown to be associated with poor adherence to antiretroviral therapy (ART). Studies examining their association with viral suppression in rural Africa are, however, scarce.
METHODS
This study reports prevalence of depressive symptoms and alcohol use disorder, and their potential association with adherence and viral suppression in adult patients on ART in ten clinics in rural Lesotho, Southern Africa.
RESULTS
Among 1,388 adult patients (69 % women), 80.7 % were alcohol abstinent, 6.3 % were hazardous drinkers (men: 10.7 %, women: 4.4 %, p < 0.001). The prevalence of depressive symptoms was 28.8 % (men 20.2 %, women 32.7 %, p < 0.001). Both alcohol consumption (adjusted odds-ratio: 2.09, 95 % CI: 1.58-2.77) and alcohol use disorder (2.73, 95 % CI: 1.68-4.42) were significantly associated with poor adherence. There was, however, no significant association with viral suppression.
CONCLUSIONS
Whereas the results of this study confirm previously reported association of alcohol use disorder with adherence to ART, there was no association with viral suppression.
TRIAL REGISTRATION
April 28th 2014; NCT02126696 .
Depression and alcohol use disorder have been shown to be associated with poor adherence to antiretroviral therapy (ART). Studies examining their association with viral suppression in rural Africa are, however, scarce.
METHODS
This study reports prevalence of depressive symptoms and alcohol use disorder, and their potential association with adherence and viral suppression in adult patients on ART in ten clinics in rural Lesotho, Southern Africa.
RESULTS
Among 1,388 adult patients (69 % women), 80.7 % were alcohol abstinent, 6.3 % were hazardous drinkers (men: 10.7 %, women: 4.4 %, p < 0.001). The prevalence of depressive symptoms was 28.8 % (men 20.2 %, women 32.7 %, p < 0.001). Both alcohol consumption (adjusted odds-ratio: 2.09, 95 % CI: 1.58-2.77) and alcohol use disorder (2.73, 95 % CI: 1.68-4.42) were significantly associated with poor adherence. There was, however, no significant association with viral suppression.
CONCLUSIONS
Whereas the results of this study confirm previously reported association of alcohol use disorder with adherence to ART, there was no association with viral suppression.
TRIAL REGISTRATION
April 28th 2014; NCT02126696 .
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1186/s12889-016-3209-4
- PMID 27608764
- Persistent URL
- https://sonar.ch/global/documents/216204
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