Back
Full-text
Journal article

Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium.

  • Fjell AM Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Sørensen Ø Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Amlien IK Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Bartrés-Faz D Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, 08007 Barcelona, Spain.
  • Brandmaier AM Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany.
  • Buchmann N Department of Cardiology, Charité - University Medicine Berlin Campus Benjamin Franklin, 12203 Berlin, Germany.
  • Demuth I Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, 10117 Berlin, Germany.
  • Drevon CA Vitas AS, Research Park, Gaustadalleen 21, 0349 Oslo, Norway.
  • Düzel S Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany.
  • Ebmeier KP Department of Psychiatry, University of Oxford, Oxford OX1 2JD UK.
  • Ghisletta P Faculty of Psychology and Educational Sciences, Swiss Distance University Institute, Swiss National Centre of Competence in Research LIVES, University of Geneva, 1205 Geneva, Switzerland.
  • Idland AV Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Kietzmann TC MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 1TN, UK.
  • Kievit RA MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 1TN, UK.
  • Kühn S Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany.
  • Lindenberger U Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany.
  • Magnussen F Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Macià D Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, 08007 Barcelona, Spain.
  • Mowinckel AM Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Nyberg L Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Sexton CE Department of Psychiatry, University of Oxford, Oxford OX1 2JD UK.
  • Solé-Padullés C Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, 08007 Barcelona, Spain.
  • Pudas S Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Roe JM Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Sederevicius D Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Suri S Department of Psychiatry, University of Oxford, Oxford OX1 2JD UK.
  • Vidal-Piñeiro D Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Wagner G Psychiatric Brain and Body Research Group, Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany.
  • Watne LO Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, 0315 Oslo, Norway.
  • Westerhausen R Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
  • Zsoldos E Department of Psychiatry, University of Oxford, Oxford OX1 2JD UK.
  • Walhovd KB Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway.
Show more…
  • 2020-11-25
Published in:
  • Cerebral cortex (New York, N.Y. : 1991). - 2020
aging
atrophy
cortex
sleep
English We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. "PSQI # 1 Subjective sleep quality" and "PSQI #5 Sleep disturbances" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with "PSQI #5 Sleep disturbances" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/216558
Statistics
Document views: 86 File downloads:
  • Full-text: 0