Journal article
Non-canonical roles of connexins.
- Van Campenhout R Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.
- Cooreman A Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.
- Leroy K Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.
- Rusiecka OM Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
- Van Brantegem P Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
- Annaert P Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
- Muyldermans S Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
- Devoogdt N In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium.
- Cogliati B Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
- Kwak BR Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
- Vinken M Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: mathieu.vinken@vub.be.
- 2020-03-30
Published in:
- Progress in biophysics and molecular biology. - 2020
English
Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.pbiomolbio.2020.03.002
- PMID 32220599
- Persistent URL
- https://sonar.ch/global/documents/216583
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