Journal article
The structure of the homeodomain and its functional implications.
- Gehring WJ University of Basel, Switzerland.
- Müller M
- Affolter M
- Percival-Smith A
- Billeter M
- Qian YQ
- Otting G
- Wüthrich K
- 1990-10-01
Published in:
- Trends in genetics : TIG. - 1990
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
DNA
Drosophila
Genes, Homeobox
Molecular Sequence Data
Protein Conformation
English
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/0168-9525(90)90253-3
- PMID 1980756
- Persistent URL
- https://sonar.ch/global/documents/216645
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