Back
The development of the acinar heterotopic pattern of phosphoenolpyruvate carboxykinase activity in the newborn rat.
Journal article

The development of the acinar heterotopic pattern of phosphoenolpyruvate carboxykinase activity in the newborn rat.

  • 1990-01-01
Published in:
  • Histochemistry. - 1990
Aging
Animals
Animals, Newborn
Female
Liver
Male
Phosphoenolpyruvate Carboxykinase (GTP)
Rats
Tissue Distribution
English The postnatal appearance of phosphoenolpyruvate carboxykinase activity (PEPCK) and acinar heterotopy was investigated in newborn rats aged 2 h, 12 h, 24 h and 3 days, as well as in juvenile rats aged 25 days. The livers showed an almost homogeneous distribution of activity along the sinusoidal length at the beginning of extrauterine life where energy needs are greatest. Compared to rats aged 2 h, the PEPCK activity was higher in the livers from rats aged 12 h. The increase in activity was most pronounced in the intermediary zone. After 24 h of extrauterine life the activity decreased again creating a homogeneous acinar activity pattern. By day 3 activity had increased in the periportal zone, while decreasing in the perivenous zone, resulting in a periportal to perivenous gradient. By day 25 total activity had reached highest values both in males and females, due to a relatively high perivenous activity. The more prominent acinar gradient corresponded approximately to the one seen in adult animals.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/216662
Statistics
Document views: 20 File downloads: